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G6PD Deficiency


G6PD (Glucose-6, Phosphate Dehydrogenase) Deficiency is the most common enzyme deficiency worldwide standing at 7.5% of the world population. It is a X-Linked Recessive Inheritance and may cause Haemolytic Anaemia (Red Blood Cells are destroyed faster than they are produced)and Jaundice.

It increases the Red Blood Cells’ vulnerability to Oxidative stress

In the Pentose Phosphate Pathway, also known as the Pentose Phosphate Shunt, G6PD is responsible for catalysing the conversion of NADP to NADPH. With G6PD Deficiency, a lack of NAPDH renders the Red Blood Cells vulnerable to Oxidative damage caused by certain drugs and fava (Broad) beans. Hence, most G6PD Deficient patients are allergic to such nuts. 

Interestingly, G6PD Deficiency gives some protection against malaria. Low G6PD activity introduces a hostile environment to parasite growth. 



kidshealth.org › parents › g6pdWeb resultsG6PD Deficiency (for Parents) - Nemours KidsHealth


www.nuh.com.sg › Pages › G6PD-...Web resultsG6PD Deficiency - NUH


The length of this video is 12 minutes and 17 seconds.12:17Glucose-6-Phosphate Dehydrogenase Deficiency | Symptoms, Pathophysiology ...YouTube · JJ MedicineMar 17, 2018


www.ncbi.nlm.nih.gov › articles › P...Caring for Glucose-6-Phosphate Dehydrogenase (G6PD)–Deficient ...

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