Skip to main content

The Human Genome Project

 


In 1990, a publicly funded project called The Human Genome Project aimed to determine the exact sequencing of the human DNA, base-pair by base-pair. 20 international research centers collaborated on finding out the exact sequence of the human genome which lasted up to 13 years since.

Inside every cell of your body there is DNA measuring 3.2 Billion base pairs long. It is divided into smaller portions using enzymes, making it more manageable to sequence. These reduced genes are injected into artificial bacteria and then divide, revealing finger prints in labs which let scientists know which genes are overlapped, allowing them to attach each gene together.

Each portion is further divided into smaller portions, measuring at approximately 1000 base pairs long; they are shipped to the 20 different labs all around the world, using the aforementioned method, and are further checked to maximise the accuracy of the gene sequence. Each piece of genome is determined using a computerised method called the Sanger method.

Decoding the Human Genome helps us to better understand the Biochemistry of the human body with unprecedented accuracy. With this, we can understand the biological mapping of complex disorders resulting from different factors such as genetic and environmental disturbances, such as diabetes; heart disease; cancer; and psychiatric illnesses, including alcoholism.


https://pubmed.ncbi.nlm.nih.gov/9779654/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875757/

https://www.youtube.com/watch?v=AhsIF-cmoQQ



Comments

Popular posts from this blog

Parkinson's Disease

Parkinson’s disease is a progressive nervous system disorder that affects one’s movements. Parkinson’s disease signs and symptoms are different for every individual and may go unnoticed in the early stage. Symptoms typically start on one side of the body and remain worse on that side even after the symptoms begin appearing in both sides of the body.  Generally, the symptoms of Parkinson’s disease include tremors, slowed movement, rigid muscles, impaired posture and balance, loss of automatic movements such as blinking or swinging of arms when walking, and speech and writing changes.  Parkinson’s disease occurs when neurons in an area of the brain that controls movement becomes impaired or dies. These neurons normally produce dopamine. As more neurons become impaired or die, the amount of dopamine produced in the body is reduced significantly, causing the movement problems associated with Parkinson’s disease.  People with Parkinson’s also lose the nerve endings that produce norepinephri

Tinnitus

Tinnitus is a hearing condition often described as ringing in the ears. Tinnitus can also cause other types of noise in your ears such as: buzzing, roaring, clicking, hissing and humming.  The pitch heard from tinnitus can vary from a high squeal to a low roar, this can affect the patient’s ability to detect tinnitus from external sounds Tinnitus can develop gradually over time or occur suddenly. It is often associated with: age-related hearing loss, inner ear damage, earwax build-up and middle ear infection However, one in every three people with tinnitus doesn't have any obvious problem with their ears or hearing. Sources: https://www.mayoclinic.org/diseases-conditions/tinnitus/diagnosis-treatment/drc-20350162 http://www.webmd.com/a-to-z-guides/understanding-tinnitus-basics

Pompe Disease

Pompe disease is a rare genetic condition where the body is unable to break down complex sugars. This is due to a deficiency in an enzyme called acid alfa glucosidase (GAA). Mutations in the GAA gene causes this disorder and results in a build up of glycogen in cells.  Pompe disease can appear in patients from within a few months of birth, at about 1 years old and even during the teenage years.  Those with Pompe disease usually inherit the disease from their parents. However, the allele for the disease is recessive, and may not be expressed in the parents. This disease is typically associated with weak muscles, poor muscle tone and an enlarged liver. However, there are many complications with regards to the respiratory system and motor skills which can also develop.  Enzyme replacement treatment is used for all Pompe patients. A drug called aglucosidase alfa is given intravenously, which acts as a replacement for GAA. Sources: https://my.clevelandclinic.org/health/diseases/15808-pompe-